Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
[18F]-d4-FET
- Development stage
- Unknown
- Lead developer
- First Affiliated Hospital of Jinan University
- Modality
- Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
[18F]-d4-FET is a deuterated analog of the O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) positron emission tomography (PET) tracer. It is specifically designed to improve metabolic stability by incorporating four deuterium atoms into the fluoroethyl side chain, which reduces in vivo defluorination compared to standard [18F]FET. The tracer acts as a substrate for the large neutral amino acid transporter 1 (LAT1), which is significantly overexpressed in various malignancies, particularly gliomas. By measuring amino acid transport rather than glucose metabolism, [18F]-d4-FET provides superior contrast for brain tumor imaging, aiding in tumor localization, staging, surgical and radiotherapy guidance, and the differentiation of tumor recurrence from radiation-induced changes. It is currently being evaluated in clinical studies by The First Affiliated Hospital of Jinan University for the diagnosis and management of glioma.
- Other names
- O-(2-[18F]fluoroethyl)-L-tyrosine-d4deuterated [18F]FET[18F]d4-FET
02
Targets
LAT2 (Linker for activation of T cells family member 2)SLC7A5 (Large neutral amino acid transporter small subunit 1)
Beyond the preview
Go deeper on [18F]-d4-FET.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on [18F]-d4-FET.